ITIH4

Across TCGA cell cohorts, ITIH4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITIH4-associated genes across cancer lineages are GJD2, OR1D2, and OC90. Each is linked with ITIH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITIH4-to-partner and partner-to-ITIH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by ITIH4-low versus ITIH4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH4→partner) and Y-score (partner→ITIH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR1D2 →	+0.011	+4.022	<.001	.006	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.022	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GJD2 by ITIH4 expression — LARGE_INTESTINE

Explore this box plot interactively →