ITIH2

Across TCGA patient cohorts, ITIH2 mutation is significantly associated with the RNA expression of many other genes, with 5,825 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITIH2-associated genes across cancer lineages are RNF126, PRC1, and CRYZL1. Each is linked with ITIH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITIH2-to-partner and partner-to-ITIH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF126 grouped by ITIH2-low versus ITIH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH2→partner) and Y-score (partner→ITIH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNF126 →	+0.469	+1.930	<.001	<.001	3	4
UCEC	PRC1 →	+0.729	+1.898	<.001	<.001	3	4
UCEC	CRYZL1 →	+0.237	+1.483	.002	<.001	3	4
UCEC	DNAJC9 →	+0.564	+1.758	<.001	<.001	3	4
UCEC	TIMM29 →	+0.287	+1.606	<.001	<.001	3	4
UCEC	SNHG21 →	+0.463	+1.451	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,825 associations by consensus.

RNF126 by ITIH2 expression — UCEC

Explore this box plot interactively →