ITIH2

Across TCGA cell cohorts, ITIH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,338 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible ITIH2-associated GO terms across cancer lineages are Regulation of cholesterol import, Microtubule nucleation, and Negative regulation of mRNA processing. Each is linked with ITIH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITIH2-to-partner and partner-to-ITIH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cholesterol import grouped by ITIH2-low versus ITIH2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH2→partner) and Y-score (partner→ITIH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of cholesterol import →	-0.162	-0.044	.007	.008	3	4
SKIN	Microtubule nucleation →	+0.070	+0.034	<.001	.002	3	4
LUNG_NSCLC_LUSC	Negative regulation of mRNA processing →	+0.076	+0.094	.001	.006	3	4
LIVER	Negative regulation of cholesterol import →	+2.179	+6.136	<.001	<.001	3	4
LIVER	Cerebral cortex tangential migration →	+0.764	+3.931	.007	.003	3	4
LUNG_NSCLC_LUSC	Negative regulation of mRNA splicing, via spliceosome →	+0.075	+0.098	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,338 associations by consensus.

Regulation of cholesterol import by ITIH2 expression — SKIN

Explore this box plot interactively →