ITIH1

Across TCGA pan-cancer cohorts, ITIH1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ITIH1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ITIH1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ITIH1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where ITIH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.207	0.775	.001	33	view →
CCRCC	DFS	Median	All	0.903	0.706	.001	30	view →
LSCC	DFS	Median	All	0.867	1.000	.002	18	view →
PDAC	OS	Median	IV	0.951	0.381	.006	6	view →
UCEC	DFS	Quartile	All	0.804	0.960	.008	2	view →
HNSC	OS	Median	IV	0.606	0.820	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ITIH1–LUAD (OS)

Open the LUAD breakdown →