ITIH1

Across TCGA patient cohorts, ITIH1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITIH1-associated genes across cancer lineages are p27_pT198, ERK2, and JNK_pT183_Y185. Each is linked with ITIH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITIH1-to-partner and partner-to-ITIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by ITIH1-low versus ITIH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH1→partner) and Y-score (partner→ITIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.083	+1.807	.023	.004	3	3
UCEC	ERK2 →	+0.158	+1.247	.015	.045	3	2
UCEC	JNK_pT183_Y185 →	-0.118	-2.115	.039	.017	3	2
UCEC	MEK1 →	+0.305	+2.415	.014	.003	3	2
UCEC	Notch1 →	+0.106	+1.887	.027	.029	3	2
UCEC	Annexin-1 →	+0.366	+2.135	.041	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p27_pT198 by ITIH1 expression — UCEC

Explore this box plot interactively →