ITIH1

Across TCGA cell cohorts, ITIH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 595 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible ITIH1-associated GO terms across cancer lineages are Positive regulation of vascular endothelial cell proliferation, Positive regulation of nitric oxide mediated signal transduction, and Response to Thyroid stimulating hormone. Each is linked with ITIH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITIH1-to-partner and partner-to-ITIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of vascular endothelial cell proliferation grouped by ITIH1-low versus ITIH1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH1→partner) and Y-score (partner→ITIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of vascular endothelial cell proliferation →	+0.099	+0.036	<.001	<.001	3	4
LIVER	Positive regulation of nitric oxide mediated signal transduction →	+0.283	+0.969	<.001	.001	3	3
LIVER	Response to Thyroid stimulating hormone →	+1.625	+1.063	<.001	<.001	3	3
CNS	Regulation of toll-like receptor 3 signaling pathway →	+0.070	+0.051	<.001	.002	3	3
OVARY	Methionine transport →	-0.157	-0.041	<.001	.002	3	3
OVARY	Regulation of TORC1 signaling →	+0.038	+0.047	.003	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 595 associations by consensus.

Positive regulation of vascular endothelial cell proliferation by ITIH1 expression — OVARY

Explore this box plot interactively →