Across TCGA pan-cancer cohorts, ITGBL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITGBL1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ITGBL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ITGBL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, GBM, and HNSC are the cancer types where ITGBL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.711	0.949	.003	25	view →
GBM	DFS	Tertile	All	0.312	0.608	.021	7	view →
HNSC	DFS	Median	II,III,IV	0.875	0.723	.014	5	view →
CCRCC	OS	Median	II,III,IV	0.352	0.891	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ITGBL1 tumor-vs-normal RNA expression · all ITGBL1 data types