ITGB8

Across TCGA pan-cancer cohorts, ITGB8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ITGB8 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ITGB8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGB8 expression acts as an unfavorable survival marker, although some lineages such as OV and GBM show a favorable association.

PDAC, LUAD, and OV are the cancer types where ITGB8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.614	0.863	.007	21	view →
LUAD	OS	Median	II,III,IV	0.280	0.924	.002	10	view →
OV	DFS	Median	All	1.000	0.854	.032	8	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	6	view →
GBM	OS	Median	All	0.486	0.303	.044	2	view →
LSCC	OS	Quartile	II,III,IV	0.779	0.996	.033	2	view →
HNSC	DFS	Median	All	0.979	0.923	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ITGB8–PDAC (DFS)

Open the PDAC breakdown →