ITGB8

Across TCGA pan-cancer cohorts, ITGB8 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ITGB8’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ITGB8 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ITGB8 is over-expressed in tumor.

PDAC, LSCC, and HNSC are the cancer types where ITGB8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGB8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+1.488	<.001	8	view →
LSCC	Male	III,IV	+1.375	<.001	8	view →
HNSC	Male	IV	+0.912	<.001	8	view →
LUAD	Male	All	+0.741	<.001	6	view →
OV	All	All	+0.868	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ITGB8–PDAC

Open the PDAC breakdown →