ITGB8

Across TCGA patient cohorts, ITGB8 protein abundance is significantly associated with the RNA expression of many other genes, with 8,860 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ITGB8-associated genes across cancer lineages are RAC1, MALSU1, and POLR1F. Each is linked with ITGB8 in more than 5 cancer types. Because this analysis shows association rather than direction, both ITGB8-to-partner and partner-to-ITGB8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITGB8 versus RAC1 in OV, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB8→partner) and Y-score (partner→ITGB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAC1 →	+0.469	+0.603	.002	.008	2	6
OV	MALSU1 →	+0.555	+0.642	<.001	<.001	3	5
HNSC	POLR1F →	+0.623	+0.660	.003	<.001	3	4
PDAC	FAM3C2P →	+0.612	+0.744	.003	.006	3	4
BRCA	TMEM158 →	+1.464	+0.977	<.001	<.001	3	4
UCEC	MET →	+1.195	+0.666	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,860 associations by consensus.

ITGB8 vs RAC1 — OV

Explore this scatter interactively →