ITGB8

Across TCGA patient cohorts, ITGB8 mutation is significantly associated with the RNA expression of many other genes, with 4,636 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB8-associated genes across cancer lineages are GMNN, TTC19, and WBP4. Each is linked with ITGB8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB8-to-partner and partner-to-ITGB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMNN grouped by ITGB8-low versus ITGB8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB8→partner) and Y-score (partner→ITGB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GMNN →	+0.686	+2.021	<.001	<.001	3	3
UCEC	TTC19 →	+0.463	+2.209	<.001	<.001	3	3
UCEC	WBP4 →	+0.458	+1.628	<.001	<.001	3	3
UCEC	SPRYD7 →	+0.398	+2.000	<.001	<.001	3	3
UCEC	EXOSC9 →	+0.440	+1.828	<.001	<.001	3	3
UCEC	NUDT15 →	+0.463	+1.649	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,636 associations by consensus.

GMNN by ITGB8 expression — UCEC

Explore this box plot interactively →