ITGB8

Across TCGA cell cohorts, ITGB8 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,057 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ITGB8-associated GO terms across cancer lineages are Positive regulation of alpha-beta T cell differentiation, Endosomal transport, and Regulation of plasma membrane bounded cell projection assembly. Each is linked with ITGB8 in more than 11 cancer types. Because this analysis shows association rather than direction, both ITGB8-to-partner and partner-to-ITGB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of alpha-beta T cell differentiation grouped by ITGB8-low versus ITGB8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB8→partner) and Y-score (partner→ITGB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of alpha-beta T cell differentiation →	+0.086	+1.599	.004	.004	3	12
BONE	Endosomal transport →	+0.052	+1.579	<.001	<.001	3	11
OVARY	Regulation of plasma membrane bounded cell projection assembly →	+0.052	+2.510	<.001	.001	3	11
BONE	Positive regulation of CD4-positive, alpha-beta T cell activation →	+0.145	+2.156	<.001	<.001	3	11
URINARY_TRACT	Proteasomal ubiquitin-independent protein catabolic process →	+0.120	+2.125	.001	.005	3	10
BREAST	Negative regulation of respiratory burst involved in inflammatory response →	+0.131	+1.552	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,057 associations by consensus.

Positive regulation of alpha-beta T cell differentiation by ITGB8 expression — BONE

Explore this box plot interactively →