ITGB7

Across TCGA patient cohorts, ITGB7 mutation is significantly associated with the RNA expression of many other genes, with 2,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB7-associated genes across cancer lineages are BAG3, OR4A42P, and OR2AT2P. Each is linked with ITGB7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB7-to-partner and partner-to-ITGB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG3 grouped by ITGB7-low versus ITGB7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB7→partner) and Y-score (partner→ITGB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BAG3 →	+0.619	+2.871	.001	.001	3	3
LUAD	OR4A42P →	+0.029	+7.930	<.001	.008	3	3
SARC	OR2AT2P →	+0.137	+6.649	<.001	<.001	3	3
SKCM	OR5D17P →	+0.029	+3.282	<.001	.005	3	3
GBM	MIR3907 →	+0.423	+4.969	<.001	.009	3	2
UCEC	MIR6895 →	+0.679	+2.203	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,035 associations by consensus.

BAG3 by ITGB7 expression — UCEC

Explore this box plot interactively →