ITGB7

Across TCGA patient cohorts, ITGB7 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB7-associated genes across cancer lineages are Cyclin-E2, STAT3_pY705, and 14-3-3_beta. Each is linked with ITGB7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB7-to-partner and partner-to-ITGB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ITGB7-low versus ITGB7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB7→partner) and Y-score (partner→ITGB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.194	+2.469	.006	.010	3	2
SKCM	STAT3_pY705 →	-0.340	-3.000	.028	.036	3	2
UCEC	14-3-3_beta →	-0.111	-3.295	.009	.009	3	1
UCEC	eEF2 →	+0.401	+3.169	.008	.019	3	1
UCEC	EGFR_pY1068 →	-0.290	-2.584	.006	.010	3	1
UCEC	eIF4G →	+0.350	+1.700	.007	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-E2 by ITGB7 expression — UCEC

Explore this box plot interactively →