ITGB7

Across TCGA cell cohorts, ITGB7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,393 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITGB7-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Protein localization to plasma membrane, and Extrinsic apoptotic signaling pathway via death domain receptors. Each is linked with ITGB7 in more than 8 cancer types. Because this analysis shows association rather than direction, both ITGB7-to-partner and partner-to-ITGB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by ITGB7-low versus ITGB7-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB7→partner) and Y-score (partner→ITGB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.053	+0.871	<.001	<.001	3	9
OESOPHAGUS	Protein localization to plasma membrane →	+0.069	+1.265	<.001	<.001	3	9
LARGE_INTESTINE	Extrinsic apoptotic signaling pathway via death domain receptors →	+0.087	+1.028	<.001	<.001	3	9
OESOPHAGUS	Extrinsic apoptotic signaling pathway →	+0.078	+0.958	<.001	.008	3	9
URINARY_TRACT	Positive regulation of proteolysis →	+0.116	+1.112	<.001	<.001	3	9
SOFT_TISSUE	Regulation of plasma membrane repair →	+0.260	+0.267	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,393 associations by consensus.

Small GTPase-mediated signal transduction by ITGB7 expression — URINARY_TRACT

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