ITGB7

Across TCGA cell cohorts, ITGB7 mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGB7-associated genes across cancer lineages are CLEC4F, SFT2D3, and NPHS2. Each is linked with ITGB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB7-to-partner and partner-to-ITGB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC4F grouped by ITGB7-low versus ITGB7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB7→partner) and Y-score (partner→ITGB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLEC4F →	+0.070	+3.643	<.001	.006	3	2
BLOOD_Leukemia	SFT2D3 →	+0.551	+4.772	<.001	<.001	3	2
URINARY_TRACT	NPHS2 →	+0.187	+5.044	<.001	<.001	3	1
URINARY_TRACT	FAM135B →	+0.021	+4.217	<.001	.005	3	1
URINARY_TRACT	CLEC14A →	+0.013	+4.217	.007	.005	3	1
URINARY_TRACT	TMEM252 →	+0.637	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

CLEC4F by ITGB7 expression — BLOOD_Leukemia

Explore this box plot interactively →