ITGB5-AS1

Across TCGA pan-cancer cohorts, ITGB5-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ITGB5-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ITGB5-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ITGB5-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, KICH, and ACC are the cancer types where ITGB5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.784	0.629	.009	56	view →
KICH	DFS	Quartile	All	0.491	0.961	.001	50	view →
ACC	DFS	Quartile	All	0.132	0.539	<.001	36	view →
HNSC	DFS	Quartile	IV	0.767	0.595	.010	32	view →
SARC	OS	Tertile	All	0.647	0.794	.001	28	view →
KIRP	OS	Quartile	All	0.616	0.808	.004	25	view →
OV	OS	Median	IV	0.587	0.895	<.001	22	view →
TGCT	DFS	Tertile	All	0.723	0.912	.005	18	view →
LIHC	DFS	Tertile	II,III,IV	0.281	0.475	.002	17	view →
STAD	DFS	Tertile	All	0.310	0.490	.014	16	view →
BRCA	DFS	Median	IV	0.718	0.341	.010	13	view →
PAAD	OS	Median	All	0.288	0.476	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ITGB5-AS1–LUAD (DFS)

Open the LUAD breakdown →