ITGB4

Across TCGA pan-cancer cohorts, ITGB4 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated ITGB4 data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ITGB4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGB4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

ACC, DLBC, and UCEC are the cancer types where ITGB4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
UCEC	DFS	Median	All	0.963	0.826	.012	16	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	OS	Median	IV	0.805	0.283	.031	6	view →
LIHC	OS	Median	III,IV	0.051	0.616	<.001	6	view →
LUAD	OS	Median	II,III,IV	0.090	0.677	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	All	0.491	0.650	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

ITGB4–ACC (DFS)

Open the ACC breakdown →