ITGB4

Across TCGA patient cohorts, ITGB4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,414 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITGB4-associated genes across cancer lineages are ITGA6, PTP4A3, and ITGA6-AS1. Each is linked with ITGB4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ITGB4-to-partner and partner-to-ITGB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITGB4 versus ITGA6 in LSCC, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB4→partner) and Y-score (partner→ITGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ITGA6 →	+1.132	+0.759	<.001	<.001	3	7
HNSC	PTP4A3 →	-1.160	-0.547	<.001	<.001	3	6
HNSC	ITGA6-AS1 →	+0.969	+0.608	<.001	<.001	3	6
LSCC	GJB3 →	+1.208	+0.646	<.001	<.001	3	6
LSCC	GJB5 →	+1.663	+0.629	<.001	<.001	3	5
PDAC	PICART1 →	+0.631	+0.454	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,414 associations by consensus.

ITGB4 vs ITGA6 — LSCC

Explore this scatter interactively →