ITGB4

Across TCGA patient cohorts, ITGB4 mutation is significantly associated with the RNA expression of many other genes, with 7,504 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB4-associated genes across cancer lineages are BAG4, PPIP5K1, and ISOC1. Each is linked with ITGB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGB4-to-partner and partner-to-ITGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG4 grouped by ITGB4-low versus ITGB4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB4→partner) and Y-score (partner→ITGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BAG4 →	+0.522	+3.837	<.001	<.001	3	4
COAD	PPIP5K1 →	+0.317	+3.335	.002	.005	3	4
STAD	ISOC1 →	+0.575	+3.347	<.001	.004	3	4
STAD	RASSF1 →	+0.414	+2.750	.005	.003	3	4
COAD	DLG3 →	+0.407	+2.710	.001	.003	3	4
COAD	CENPM →	+0.612	+3.611	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,504 associations by consensus.

BAG4 by ITGB4 expression — COAD

Explore this box plot interactively →