ITGB4

Across TCGA patient cohorts, ITGB4 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB4-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with ITGB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB4-to-partner and partner-to-ITGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ITGB4-low versus ITGB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB4→partner) and Y-score (partner→ITGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.343	+1.432	.001	.005	3	3
COAD	Caspase-7-cleavedD198 →	+1.129	+3.008	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.224	+2.115	.004	.016	3	3
LUSC	Cyclin-B1 →	+0.495	+2.179	.019	.035	3	2
BLCA	STAT5a →	-0.720	-3.000	.001	.034	3	2
COAD	ASNS →	+0.362	+1.815	.014	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MEK1 by ITGB4 expression — UCEC

Explore this box plot interactively →