ITGB4

Across TCGA cell cohorts, ITGB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,856 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ITGB4-associated GO terms across cancer lineages are Nail development, Hemidesmosome assembly, and Cell-substrate junction assembly. Each is linked with ITGB4 in more than 14 cancer types. Because this analysis shows association rather than direction, both ITGB4-to-partner and partner-to-ITGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nail development grouped by ITGB4-low versus ITGB4-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB4→partner) and Y-score (partner→ITGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Nail development →	+0.720	+2.513	.002	<.001	3	15
URINARY_TRACT	Hemidesmosome assembly →	+0.297	+4.324	<.001	<.001	3	13
URINARY_TRACT	Cell-substrate junction assembly →	+0.172	+3.560	<.001	<.001	3	11
LARGE_INTESTINE	Protein localization to cell periphery →	+0.080	+2.001	<.001	.002	3	11
STOMACH	Negative regulation of defense response →	+0.062	+2.684	<.001	.008	3	11
KIDNEY	Response to unfolded protein →	+0.111	+3.891	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,856 associations by consensus.

Nail development by ITGB4 expression — KIDNEY

Explore this box plot interactively →