ITGB4

Across TCGA cell cohorts, ITGB4 mutation is significantly associated with the RNA expression of many other genes, with 2,467 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGB4-associated genes across cancer lineages are C12orf29, METTL14, and EIF4E. Each is linked with ITGB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGB4-to-partner and partner-to-ITGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf29 grouped by ITGB4-low versus ITGB4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB4→partner) and Y-score (partner→ITGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C12orf29 →	+0.383	+1.721	.006	.003	3	3
LARGE_INTESTINE	METTL14 →	+0.563	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	EIF4E →	+0.696	+2.714	<.001	<.001	3	3
LARGE_INTESTINE	ZFYVE9 →	+0.752	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	CCNF →	+0.556	+3.459	.004	<.001	3	3
LARGE_INTESTINE	MAD2L1 →	+0.639	+2.130	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,467 associations by consensus.

C12orf29 by ITGB4 expression — LARGE_INTESTINE

Explore this box plot interactively →