ITGB3

Across TCGA patient cohorts, ITGB3 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB3-associated genes across cancer lineages are Caspase-7-cleavedD198, Lck, and IGFBP2. Each is linked with ITGB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB3-to-partner and partner-to-ITGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ITGB3-low versus ITGB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3→partner) and Y-score (partner→ITGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.688	+1.797	<.001	.001	3	3
COAD	Lck →	+0.461	+2.832	.005	.035	3	3
UCEC	IGFBP2 →	-0.739	-1.807	<.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.142	-2.038	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.400	+2.044	<.001	<.001	3	2
UCEC	P-Cadherin →	-0.085	-1.906	.035	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by ITGB3 expression — UCEC

Explore this box plot interactively →