ITGB3

Across TCGA cell cohorts, ITGB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,539 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ITGB3-associated GO terms across cancer lineages are Positive regulation of actin filament bundle assembly, Oncostatin-M-mediated signaling pathway, and PML body organization. Each is linked with ITGB3 in more than 13 cancer types. Because this analysis shows association rather than direction, both ITGB3-to-partner and partner-to-ITGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of actin filament bundle assembly grouped by ITGB3-low versus ITGB3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3→partner) and Y-score (partner→ITGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of actin filament bundle assembly →	+0.147	+2.207	<.001	<.001	3	14
BONE	Oncostatin-M-mediated signaling pathway →	+0.259	+2.776	<.001	<.001	3	14
LUNG_NSCLC_LUSC	PML body organization →	+0.278	+1.925	<.001	<.001	3	14
BONE	Positive regulation of cell-substrate junction organization →	+0.149	+2.368	<.001	<.001	3	14
BONE	Response to acid chemical →	+0.068	+2.855	.001	<.001	3	13
LIVER	Lipoprotein biosynthetic process →	+0.121	+3.402	.004	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,539 associations by consensus.

Positive regulation of actin filament bundle assembly by ITGB3 expression — BONE

Explore this box plot interactively →