ITGB3

Across TCGA cell cohorts, ITGB3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ITGB3-associated genes across cancer lineages are PNLDC1, KRT40, and BPIFA1. Each is linked with ITGB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB3-to-partner and partner-to-ITGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNLDC1 grouped by ITGB3-low versus ITGB3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3→partner) and Y-score (partner→ITGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PNLDC1 →	+1.404	+3.667	<.001	.003	3	1
SKIN	KRT40 →	+0.010	+3.242	.007	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.109	+3.103	.005	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+3.614	<.001	.006	3	1
LUNG_NSCLC_LUAD	SEL1L2 →	+0.055	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	CRISP1 →	+0.038	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PNLDC1 by ITGB3 expression — SKIN

Explore this box plot interactively →