ITGB3

Across TCGA cell cohorts, ITGB3 mutation is significantly associated with the mutation status of many other genes, with 4,800 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGB3-associated genes across cancer lineages are TMEM131, AGBL1, and TRPM4. Each is linked with ITGB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITGB3-to-partner and partner-to-ITGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM131 grouped by ITGB3-low versus ITGB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3→partner) and Y-score (partner→ITGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM131 →	+3.222	+4.989	<.001	<.001	1	5
BLOOD_Leukemia	AGBL1 →	+4.157	+5.430	<.001	<.001	1	4
SKIN	TRPM4 →	+3.718	+3.053	.006	.006	1	4
BLOOD_Leukemia	COL5A1 →	+2.572	+4.129	.009	.009	1	4
SKIN	PTPRG →	+3.548	+3.210	.001	.001	1	4
SKIN	IGSF9 →	+3.133	+3.000	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,800 associations by consensus.

TMEM131 by ITGB3 expression — LARGE_INTESTINE

Explore this box plot interactively →