ITGB2

Across TCGA pan-cancer cohorts, ITGB2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ITGB2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ITGB2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGB2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where ITGB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.877	1.000	.016	66	view →
CCRCC	OS	Quartile	All	0.696	0.965	.002	42	view →
PDAC	OS	Quartile	III,IV	0.235	0.579	.017	18	view →
LUAD	OS	Quartile	All	0.541	0.797	.024	16	view →
LSCC	DFS	Tertile	III,IV	0.984	0.593	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ITGB2–COAD (DFS)

Open the COAD breakdown →