ITGB2

Across TCGA patient cohorts, ITGB2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ITGB2-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and EGFR_pY1068. Each is linked with ITGB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITGB2-to-partner and partner-to-ITGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ITGB2-low versus ITGB2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB2→partner) and Y-score (partner→ITGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.154	+3.601	<.001	.001	3	5
UCEC	PCNA →	+0.148	+1.584	.029	.005	3	3
COAD	EGFR_pY1068 →	-0.326	-3.169	.009	.017	3	2
COAD	FOXO3a →	-0.132	-1.861	.019	.049	3	2
COAD	Lck →	+0.270	+2.247	.020	.005	3	2
UCEC	MEK1 →	+0.301	+1.353	.008	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by ITGB2 expression — COAD

Explore this box plot interactively →