ITGB2

Across TCGA cell cohorts, ITGB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,050 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ITGB2-associated GO terms across cancer lineages are Positive regulation of neutrophil degranulation, Regulation of neutrophil degranulation, and Regulation of cell-substrate adhesion. Each is linked with ITGB2 in more than 18 cancer types. Because this analysis shows association rather than direction, both ITGB2-to-partner and partner-to-ITGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of neutrophil degranulation grouped by ITGB2-low versus ITGB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB2→partner) and Y-score (partner→ITGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of neutrophil degranulation →	+2.038	+3.799	<.001	<.001	3	19
BONE	Regulation of neutrophil degranulation →	+2.042	+3.755	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of cell-substrate adhesion →	+0.099	+1.758	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Plasminogen activation →	+0.429	+2.069	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate adhesion →	+0.132	+1.851	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Urokinase plasminogen activator signaling pathway →	+1.224	+1.589	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,050 associations by consensus.

Positive regulation of neutrophil degranulation by ITGB2 expression — BONE

Explore this box plot interactively →