ITGB2

Across TCGA cell cohorts, ITGB2 mutation is significantly associated with the RNA expression of many other genes, with 279 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGB2-associated genes across cancer lineages are GSTA3, KRTAP10-1, and RXFP2. Each is linked with ITGB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB2-to-partner and partner-to-ITGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTA3 grouped by ITGB2-low versus ITGB2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB2→partner) and Y-score (partner→ITGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GSTA3 →	+0.035	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	KRTAP10-1 →	+0.022	+5.209	<.001	.005	3	2
LUNG_NSCLC_LUSC	RXFP2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CSN2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR13C9 →	+0.090	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	KIF2B →	+0.046	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 279 associations by consensus.

GSTA3 by ITGB2 expression — BLOOD_Lymphoma

Explore this box plot interactively →