Across TCGA pan-cancer cohorts, ITGB2-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ITGB2-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ITGB2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ITGB2-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and KIRC are the cancer types where ITGB2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.422	0.275	<.001	131	view →
HNSC	DFS	Median	II,III,IV	0.754	0.619	<.001	117	view →
KIRC	OS	Median	All	0.527	0.706	<.001	102	view →
CESC	DFS	Quartile	All	0.725	0.431	<.001	62	view →
UVM	DFS	Quartile	All	0.302	0.856	.001	57	view →
LGG	DFS	Median	All	0.650	0.809	<.001	47	view →
LAML	DFS	Median	All	0.234	0.508	<.001	36	view →
PRAD	DFS	Median	All	0.835	0.930	<.001	18	view →
BLCA	DFS	Median	III,IV	0.655	0.485	.002	17	view →
GBM	DFS	Tertile	All	0.206	0.355	.004	12	view →
ESCA	DFS	Quartile	All	0.670	0.429	.009	12	view →
KIRP	DFS	Tertile	II,III,IV	0.317	1.000	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

Exploration

Same gene, other analysis: ITGB2-AS1 tumor-vs-normal RNA expression · all ITGB2-AS1 data types