ITGB1

Across TCGA pan-cancer cohorts, ITGB1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ITGB1 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ITGB1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ITGB1 expression acts as an unfavorable survival marker.

OV and ESCA are the cancer types where ITGB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.250	0.692	.009	18	view →
ESCA	OS	Median	II,III,IV	0.338	0.711	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ITGB1–OV (OS)

Open the OV breakdown →