ITGB1

Across TCGA pan-cancer cohorts, ITGB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ITGB1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ITGB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGB1 expression acts as an unfavorable survival marker.

PDAC, GBM, and CCRCC are the cancer types where ITGB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.667	0.970	.001	39	view →
GBM	DFS	Quartile	All	0.210	0.522	.001	29	view →
CCRCC	DFS	Median	All	0.632	0.828	.010	28	view →
LUAD	OS	Median	II,III,IV	0.313	0.924	<.001	24	view →
LSCC	OS	Quartile	All	0.727	0.963	.005	12	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ITGB1–PDAC (DFS)

Open the PDAC breakdown →