ITGB1

Across TCGA patient cohorts, ITGB1 mutation is significantly associated with the RNA expression of many other genes, with 4,719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB1-associated genes across cancer lineages are TMEM62, RNU6-991P, and H2AZ1. Each is linked with ITGB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB1-to-partner and partner-to-ITGB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM62 grouped by ITGB1-low versus ITGB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB1→partner) and Y-score (partner→ITGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM62 →	+0.663	+3.721	<.001	<.001	3	3
LUSC	RNU6-991P →	+0.569	+5.318	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.602	+2.839	.001	<.001	3	3
UCEC	ELAC2 →	+0.465	+3.839	<.001	<.001	3	3
UCEC	TIMM21 →	+0.456	+2.807	.001	.003	3	3
UCEC	ME2 →	+0.667	+2.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,719 associations by consensus.

TMEM62 by ITGB1 expression — UCEC

Explore this box plot interactively →