ITGB1

Across TCGA patient cohorts, ITGB1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB1-associated genes across cancer lineages are 4E-BP1, MEK1, and p90 RSK. Each is linked with ITGB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB1-to-partner and partner-to-ITGB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ITGB1-low versus ITGB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB1→partner) and Y-score (partner→ITGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.235	+1.904	.023	.029	3	3
UCEC	MEK1 →	+0.288	+2.000	.040	.030	3	2
UCEC	p90 RSK →	+0.175	+3.169	.016	.018	3	2
UCEC	PCNA →	+0.248	+2.087	.002	.005	3	2
UCEC	PDCD4 →	-0.409	-2.087	.023	.005	3	2
UCEC	S6_pS240_S244 →	+0.330	+3.000	.034	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

4E-BP1 by ITGB1 expression — UCEC

Explore this box plot interactively →