ITGB1

Across TCGA cell cohorts, ITGB1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGB1-associated genes across cancer lineages are C12orf40, FHL5, and FGF3. Each is linked with ITGB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB1-to-partner and partner-to-ITGB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by ITGB1-low versus ITGB1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB1→partner) and Y-score (partner→ITGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	FHL5 →	+0.041	+4.510	<.001	.003	3	2
BLOOD_Lymphoma	FGF3 →	+0.019	+5.209	<.001	.005	3	1
LUNG_SCLC	SMR3A →	+0.193	+5.643	<.001	.002	3	1
LUNG_SCLC	FTMT →	+0.177	+5.029	<.001	.006	3	1
LUNG_SCLC	PYDC2 →	+0.203	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C12orf40 by ITGB1 expression — OVARY

Explore this box plot interactively →