ITGAX

Across TCGA pan-cancer cohorts, ITGAX mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ITGAX’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ITGAX mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ITGAX is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where ITGAX tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGAX mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+1.821	<.001	12	view →
HNSC	Male	IV	+0.935	<.001	12	view →
COAD	Male	All	+0.719	<.001	11	view →
LUAD	Male	III,IV	−0.390	.008	5	view →
PDAC	Female	All	+0.765	.001	4	view →
LSCC	All	All	−0.185	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ITGAX–CCRCC

Open the CCRCC breakdown →