ITGAX

Across TCGA patient cohorts, ITGAX protein abundance is significantly associated with the RNA expression of many other genes, with 16,342 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ITGAX-associated genes across cancer lineages are NCF4, CSF2RB, and SIRPB1. Each is linked with ITGAX in more than 9 cancer types. Because this analysis shows association rather than direction, both ITGAX-to-partner and partner-to-ITGAX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITGAX versus NCF4 in GBM, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAX→partner) and Y-score (partner→ITGAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF4 →	+0.918	+0.469	<.001	<.001	3	10
BRCA	CSF2RB →	+1.074	+0.360	<.001	<.001	3	10
UCEC	SIRPB1 →	+0.775	+0.610	<.001	<.001	3	10
GBM	HCK →	+0.999	+0.575	<.001	<.001	3	10
UCEC	TLR8 →	+1.047	+0.788	<.001	<.001	3	10
BRCA	IL4I1 →	+1.294	+0.422	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,342 associations by consensus.

ITGAX vs NCF4 — GBM

Explore this scatter interactively →