ITGAX

Across TCGA cell cohorts, ITGAX mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITGAX-associated genes across cancer lineages are EDA, CCT8L2, and KRT1. Each is linked with ITGAX in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGAX-to-partner and partner-to-ITGAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDA grouped by ITGAX-low versus ITGAX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAX→partner) and Y-score (partner→ITGAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EDA →	+0.861	+3.662	<.001	<.001	3	2
BLOOD_Leukemia	CCT8L2 →	+0.007	+2.482	<.001	.008	3	2
LUNG_NSCLC_LUAD	KRT1 →	+0.143	+3.500	<.001	.008	3	2
SOFT_TISSUE	KIF2B →	+0.084	+4.977	<.001	.002	3	1
SKIN	C4BPA →	+0.015	+2.317	.003	.004	3	1
LARGE_INTESTINE	RUFY4 →	+0.353	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

EDA by ITGAX expression — BLOOD_Leukemia

Explore this box plot interactively →