ITGAV

Across TCGA pan-cancer cohorts, ITGAV mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ITGAV’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ITGAV mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ITGAV is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

PDAC, LUAD, and HNSC are the cancer types where ITGAV tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGAV mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+0.842	<.001	9	view →
LUAD	Female	III,IV	+0.543	<.001	9	view →
HNSC	All	IV	+0.819	<.001	8	view →
LSCC	Female	II,III,IV	+0.790	<.001	8	view →
COAD	Male	III,IV	−0.395	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ITGAV–PDAC

Open the PDAC breakdown →