ITGAL

Across TCGA pan-cancer cohorts, ITGAL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ITGAL data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ITGAL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGAL expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

COAD, LUAD, and GBM are the cancer types where ITGAL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.873	1.000	.013	54	view →
LUAD	OS	Median	III,IV	0.287	0.777	.004	16	view →
GBM	DFS	Tertile	All	0.266	0.481	.002	8	view →
PDAC	DFS	Tertile	III,IV	0.592	0.161	.012	8	view →
CCRCC	OS	Median	IV	0.167	0.784	.038	6	view →
LSCC	DFS	Tertile	All	0.852	0.389	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ITGAL–COAD (DFS)

Open the COAD breakdown →