ITGAL

Across TCGA patient cohorts, ITGAL mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGAL-associated genes across cancer lineages are Ku80, Cyclin-B1, and eIF4E. Each is linked with ITGAL in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGAL-to-partner and partner-to-ITGAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ITGAL-low versus ITGAL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAL→partner) and Y-score (partner→ITGAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.174	+1.375	.008	.020	3	4
COAD	Cyclin-B1 →	+0.993	+3.016	<.001	.018	3	3
UCEC	eIF4E →	+0.158	+2.263	.007	<.001	3	3
UCEC	PCNA →	+0.186	+1.494	.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.169	+2.824	.001	.034	3	3
COAD	Stathmin →	+0.177	+3.330	.014	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Ku80 by ITGAL expression — UCEC

Explore this box plot interactively →