ITGAL

Across TCGA cell cohorts, ITGAL mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGAL-associated genes across cancer lineages are OR13G1, TOPAZ1, and OR10G2. Each is linked with ITGAL in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGAL-to-partner and partner-to-ITGAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13G1 grouped by ITGAL-low versus ITGAL-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAL→partner) and Y-score (partner→ITGAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR13G1 →	+0.034	+2.841	<.001	.009	3	2
LUNG_NSCLC_LUAD	TOPAZ1 →	+0.007	+4.078	<.001	.009	3	2
LUNG_SCLC	OR10G2 →	+0.158	+3.523	<.001	.008	3	2
LARGE_INTESTINE	CBY1 →	+0.578	+3.459	.001	.001	3	2
LARGE_INTESTINE	GPS2 →	+0.513	+3.743	.002	<.001	3	2
LARGE_INTESTINE	ZNF232 →	+0.929	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

OR13G1 by ITGAL expression — OVARY

Explore this box plot interactively →