ITGAE

Across TCGA pan-cancer cohorts, ITGAE mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITGAE data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ITGAE mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ITGAE expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and PDAC are the cancer types where ITGAE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	1.000	0.870	.004	19	view →
LSCC	DFS	Quartile	All	0.890	0.202	.004	11	view →
PDAC	OS	Median	II,III,IV	0.751	0.498	.015	10	view →
HNSC	DFS	Median	III,IV	0.505	0.780	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ITGAE–LUAD (DFS)

Open the LUAD breakdown →