ITGAD

Across TCGA patient cohorts, ITGAD RNA expression is significantly associated with the go_rna of many other GO terms, with 7,122 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ITGAD-associated GO terms across cancer lineages are B cell activation, Alpha-beta T cell activation, and Positive regulation of leukocyte cell-cell adhesion. Each is linked with ITGAD in more than 30 cancer types. Because this analysis shows association rather than direction, both ITGAD-to-partner and partner-to-ITGAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell activation grouped by ITGAD-low versus ITGAD-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAD→partner) and Y-score (partner→ITGAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	B cell activation →	+0.108	+0.423	<.001	<.001	3	31
SCLC	Alpha-beta T cell activation →	+0.105	+0.534	<.001	<.001	3	31
SCLC	Positive regulation of leukocyte cell-cell adhesion →	+0.114	+0.450	<.001	<.001	3	31
SCLC	Antigen processing and presentation of exogenous peptide antigen →	+0.322	+0.525	<.001	<.001	3	30
SCLC	Regulation of mast cell activation involved in immune response →	+0.151	+0.704	<.001	<.001	3	30
SCLC	Cell-cell adhesion mediated by integrin →	+0.258	+0.458	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,122 associations by consensus.

B cell activation by ITGAD expression — SCLC

Explore this box plot interactively →