ITGAD

Across TCGA cell cohorts, ITGAD mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGAD-associated genes across cancer lineages are SLCO1B3, WARS2, and CEP20. Each is linked with ITGAD in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGAD-to-partner and partner-to-ITGAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1B3 grouped by ITGAD-low versus ITGAD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAD→partner) and Y-score (partner→ITGAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLCO1B3 →	+1.809	+3.321	.004	.003	3	2
LARGE_INTESTINE	WARS2 →	+0.472	+3.082	.004	.007	3	2
LARGE_INTESTINE	CEP20 →	+0.419	+2.628	.009	.002	3	2
LARGE_INTESTINE	MYO5B →	+0.959	+2.628	.004	.002	3	2
LARGE_INTESTINE	IQCF6 →	+0.111	+2.034	.007	.007	3	2
LUNG_NSCLC_LUAD	OR52W1 →	+0.032	+3.169	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

SLCO1B3 by ITGAD expression — LARGE_INTESTINE

Explore this box plot interactively →