ITGA8

Across TCGA pan-cancer cohorts, ITGA8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITGA8 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ITGA8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGA8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

GBM, CCRCC, and PDAC are the cancer types where ITGA8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.289	0.901	.024	14	view →
CCRCC	DFS	Tertile	III,IV	0.815	0.515	.006	12	view →
PDAC	DFS	Median	III,IV	0.311	0.919	.038	3	view →
LUAD	DFS	Quartile	All	0.816	0.531	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ITGA8–GBM (DFS)

Open the GBM breakdown →