ITGA8

Across TCGA patient cohorts, ITGA8 mutation is significantly associated with the RNA expression of many other genes, with 5,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA8-associated genes across cancer lineages are IER3IP1, HAUS1, and RNF227. Each is linked with ITGA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITGA8-to-partner and partner-to-ITGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IER3IP1 grouped by ITGA8-low versus ITGA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA8→partner) and Y-score (partner→ITGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IER3IP1 →	+0.347	+2.217	.002	<.001	3	5
LUSC	HAUS1 →	+0.471	+3.357	.001	.004	3	4
LUSC	RNF227 →	+0.406	+1.728	.001	.002	3	4
SKCM	BCCIP →	+0.423	+1.938	<.001	.002	3	4
UCEC	HJURP →	+0.501	+2.354	.001	.003	3	4
UCEC	AUNIP →	+0.519	+2.008	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,105 associations by consensus.

IER3IP1 by ITGA8 expression — UCEC

Explore this box plot interactively →