ITGA8

Across TCGA patient cohorts, ITGA8 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA8-associated genes across cancer lineages are ACC_pS79, MIG-6, and p27_pT198. Each is linked with ITGA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA8-to-partner and partner-to-ITGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by ITGA8-low versus ITGA8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA8→partner) and Y-score (partner→ITGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACC_pS79 →	-0.306	-2.106	.009	.018	3	3
COAD	MIG-6 →	+0.087	+2.866	.024	.001	3	3
LUAD	p27_pT198 →	+0.114	+1.502	.014	.028	3	2
LUAD	c-Jun_pS73 →	-0.124	-1.502	.028	.028	3	2
UCEC	EGFR_pY1068 →	-0.232	-1.906	.001	<.001	3	2
UCEC	ERK2 →	+0.202	+1.440	<.001	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

ACC_pS79 by ITGA8 expression — COAD

Explore this box plot interactively →